Abstract
Ocean related activities are often supported by offshore equipment with particular power demands. These are usually deployed at remote locations and have limited space, thus small energy harvesting technologies, such as photovoltaic panels or wind turbines, are used to power their instruments. However, the inherent energy sources are intermittent and have lower density and predictability than an alternative source: wave energy. Here, we propose and critically assess triboelectric nanogenerators (TENGs) as a promising technology for integration into wave buoys. Three TENGs based on rolling-spheres were developed and their performance compared in both a "dry" bench testing system under rotating motions, and in a large-scale wave basin under realistic sea-states installed within a scaled navigation buoy. Both experiments show that the electrical outputs of these TENGs increase with decreasing wave periods and increasing wave amplitudes. However, the wave basin tests clearly demonstrated a significant dependency of the electrical outputs on the pitch degree of freedom and the need to take into account the full dynamics of the buoy, and not only that of TENGs, when subjected to the excitations of waves. This work opens new horizons and strategies to apply TENGs in marine applications, considering realistic hydrodynamic behaviors of floating bodies.

Abstract
The recent Bluetooth 5.1 specification introduced the use of Angle-of-Arrival (AoA) information which enables the design of novel low-cost indoor positioning systems. Existing approaches rely on multiple fixed gateways equipped with antenna arrays, in order to determine the location of an arbitrary number of simple mobile omni-directional emitters. In this paper, we instead present an approach where mobile receivers are equipped with antenna arrays, and the fixed infrastructure is composed of battery-powered beacons. We implement a simulator to evaluate the solution using a real-world data set of AoA measurements. We evaluated the solution as a function of the number of beacons, their transmission period, and algorithmic parameters of the position estimation. Sub-meter accuracy is achievable using 1 beacon per 15 m(2) and a beacon transmission period of 500 ms.

Abstract
Lung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the information on other lung structures that can have relevant features for tumour genotype classification, especially for epidermal growth factor receptor (EGFR), which is the mutation with the most successful targeted therapies. With this perspective paper, we aim to explore a comprehensive analysis of the need to combine the information from tumours with other lung structures for the next generation of CADs, which could create a high impact on targeted therapies and personalised medicine. The forthcoming artificial intelligence (AI)-based approaches for lung cancer assessment should be able to make a holistic analysis, capturing information from pathological processes involved in cancer development. The powerful and interpretable AI models allow us to identify novel biomarkers of cancer development, contributing to new insights about the pathological processes, and making a more accurate diagnosis to help in the treatment plan selection.

Abstract
Lower limb amputation is a condition affecting millions of people worldwide. Patients are often prescribed with lower limb prostheses to aid their mobility, but these prostheses require frequent adjustments through an iterative and manual process, which heavily depends on patient feedback and on the prosthetist's experience. New computer-aided design and manufacturing technologies have been emerging as a way to improve the fitting process by creating virtual socket models. Statistical Shape modelling was used to create 3D models of transtibial (TT) and transfemoral (TF) sockets. Their generalization errors were, respectively, 6.8 +/- 1.8 mm and 10.5 +/- 1.6 mm, while specificity errors were 9.7 +/- 0.6 mm and 9.8 +/- 0.2 mm. In both models, a visual analysis showed that biomechanically meaningful features were captured: the largest variations found for both types were in the length of the residual limb and in the perimeter variation along the limb. The results obtained proved that statistical shape modelling methods can be applied to TF and TT sockets, with several potential applications in the orthoprosthetic field: generation of new plausible shapes and on-demand socket design adjustments.

Abstract
The evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tumor, it is an invasive and painful procedure for the patient. Nodule image features extracted from computed tomography (CT) scans have been used to create machine learning models that predict gene mutation status in a noninvasive, fast, and easy-to-use manner. However, recent studies have shown that radiomic features extracted from an extended region of interest (ROI) beyond the tumor, might be more relevant to predict the mutation status in lung cancer, and consequently may be used to significantly decrease the mortality rate of patients battling this condition. In this work, we investigated the relation between image phenotypes and the mutation status of Epidermal Growth Factor Receptor (EGFR), the most frequently mutated gene in lung cancer with several approved targeted-therapies, using radiomic features extracted from the lung containing the nodule. A variety of linear, nonlinear, and ensemble predictive classification models, along with several feature selection methods, were used to classify the binary outcome of wild-type or mutant EGFR mutation status. The results show that a comprehensive approach using a ROI that included the lung with nodule can capture relevant information and successfully predict the EGFR mutation status with increased performance compared to local nodule analyses. Linear Support Vector Machine, Elastic Net, and Logistic Regression, combined with the Principal Component Analysis feature selection method implemented with 70% of variance in the feature set, were the best-performing classifiers, reaching Area Under the Curve (AUC) values ranging from 0.725 to 0.737. This approach that exploits a holistic analysis indicates that information from more extensive regions of the lung containing the nodule allows a more complete lung cancer characterization and should be considered in future radiogenomic studies.

Abstract
Statistics have demonstrated that one of the main factors responsible for the high mortality rate related to lung cancer is the late diagnosis. Precision medicine practices have shown advances in the individualized treatment according to the genetic profile of each patient, providing better control on cancer response. Medical imaging offers valuable information with an extensive perspective of the cancer, opening opportunities to explore the imaging manifestations associated with the tumor genotype in a non-invasive way. This work aims to study the relevance of physiological features captured from Computed Tomography images, using three different 2D regions of interest to assess the Epidermal growth factor receptor (EGFR) mutation status: nodule, lung containing the main nodule, and both lungs. A Convolutional Autoencoder was developed for the reconstruction of the input image. Thereafter, the encoder block was used as a feature extractor, stacking a classifier on top to assess the EGFR mutation status. Results showed that extending the analysis beyond the local nodule allowed the capture of more relevant information, suggesting the presence of useful biomarkers using the lung with nodule region of interest, which allowed to obtain the best prediction ability. This comparative study represents an innovative approach for gene mutations status assessment, contributing to the discussion on the extent of pathological phenomena associated with cancer development, and its contribution to more accurate Artificial Intelligence-based solutions, and constituting, to the best of our knowledge, the first deep learning approach that explores a comprehensive analysis for the EGFR mutation status classification.