Abstract
The Real Time Controllers (RTCs) for the W. M. Keck Observatory Adaptive Optics (AO) systems have been upgraded from a Field Programmable Gate Array (FPGA) to a Graphics Processing Unit (GPU) based solution. The previous RTCs, operating since 2007, had reached their limitations after upgrades to support new hardware including an Infra-Red (IR) Tip/Tilt (TT) Wave Front Sensor (WFS) on Keck I and a Pyramid WFS on Keck II. The new RTC, fabricated by a Microgate-led consortium with SUT leading the computation engine development, provides a flexible platform that improves processing bandwidth and allows for easier integration with new hardware and control algorithms. Along with the new GPU-based RTC, the upgrade includes a new hardware Interface Module (IM), new OCAM2K EMCCD cameras, and a new Telemetry Recording Server (TRS). The first system upgrade to take advantage of the new RTC is the Keck I All-sky Precision Adaptive Optics (KAPA) Laser Tomography AO (LTAO) system, which uses the larger and more sensitive OCAM2K EMCCD camera, tomographic reconstruction from four Laser Guide Stars (LGS), and improvements to the IR TT WFS. On Keck II the new RTC will enable a new higher-order Deformable Mirror (DM) as part of the HAKA (High order Advanced Keck Adaptive optics) project, which will also use an EMCCD camera. In the future, the new RTC will allow the possibility for new developments such as the proposed 'IWA (Infrared Wavefront sensor Adaptive optics) system. The new RTC saw first light in 2021. The Keck I system was released for science observations in late 2023, with the Keck II system released for science in early 2024.

Abstract
METIS, the Mid-infrared ELT Imager and Spectrograph, will operate an internal Single Conjugate Adaptive Optics (SCAO) system, which will mainly serve the science cases targeting exoplanets and disks around bright stars. The Extremely Large Telescope (ELT) is expected to have its first light in 2028, and the entire instrument recently passed its final design phase. The adaptive optics (AO) of METIS SCAO is designed to correct for atmospheric distortions, and is essential for diffraction-limited observations with METIS. The computational and data transfer requirements for these next generation ELT AO Real-Time Computers (RTCs) are enormous, and require advanced data processing and pipelining techniques. METIS SCAO will use a pyramid wavefront sensor (WFS), which captures incoming wavefronts at 1 kHz with a raw throughput of 148 MB/s. The RTC will ingest these WFS images on a frame-by-frame basis, compute the corrections and send them to the deformable mirror M4 and the tip/tilt mirror M5. The RTC is split up into two distinct systems: the Hard Real-Time Computer (HRTC) and the Soft Real-Time Computer (SRTC). The HRTC is responsible for computing the time sensitive wavefront control loop, while the SRTC is responsible for supervising and optimising the HRTC. A working prototype for the HRTC has been completed and operates with an RTC computation time of roughly 372 mu s. This computation is memory limited and runs on two NVIDIA A100 GPUs. This paper shows a breakdown of the HRTC on a CUDA kernel level, focusing on the tasks that run on the GPUs. We also present the performance of the HRTC and possible improvements for it.

Abstract
Context. The deployment of meter-scale (hitherto pre-focal) adaptive deformable mirrors finds some prominent examples in the leading ground-based visible to near-infrared facilities (e.g. the Very Large Telescope (VLT), the Large Binocular Telescope (LBT), or the Magellan Telescope) and is being adopted by several others (e.g. the Multiple Mirror Telescope (MMT) or Subaru). Furthermore, two out of the three giant segmented-mirror telescopes now under design will feature them. In all these cases, the proprietary technology is based on voice-coils and is limited in force, stroke, and velocity. Aims. Because of the nature of their purpose, that is, adaptive wave-front correction, any kind of optimality relies on the control of a subset of principal wave-front components or eigenmodes, for short, a basis of functions in a mathematical sense. Here we provide algorithmic procedures for generating such eigenbases, also called Karhunen–Loève (KL) modes, that integrate force limitations in their definitions whilst maintaining standard orthonormality, statistical independence, and deformable mirror span. Methods. The double-diagonalisation method was revisited to build KL modes ranked by the force applied on the actuators. Results. We analysed this new KL basis for von Kármán turbulence statistics and present the fitting error and the distribution of positions and forces. We further illustrate their use in the case of the quaternary mirror control for the European Extremely Large Telescope, and we include the outer actuator minioning and force policy constraints. © The Authors 2024.

Abstract
Brain stroke, or a cerebrovascular accident, is a devastating medical condition that disrupts the blood supply to the brain, depriving it of oxygen and nutrients. Each year, according to the World Health Organization, 15 million people worldwide experience a stroke. This results in approximately 5 million deaths and another 5 million individuals suffering permanent disabilities. The complex interplay of various risk factors highlights the urgent need for sophisticated analytical methods to more accurately predict stroke risks and manage their outcomes. Machine learning and deep learning technologies offer promising solutions by analyzing extensive datasets including patient demographics, health records, and lifestyle choices to uncover patterns and predictors not easily discernible by humans. These technologies enable advanced data processing, analysis, and fusion techniques for a comprehensive health assessment. We conducted a comprehensive review of 25 review papers published between 2020 and 2024 on machine learning and deep learning applications in brain stroke diagnosis, focusing on classification, segmentation, and object detection. Furthermore, all these reviews explore the performance evaluation and validation of advanced sensor systems in these areas, enhancing predictive health monitoring and personalized care recommendations. Moreover, we also provide a collection of the most relevant datasets used in brain stroke analysis. The selection of the papers was conducted according to PRISMA guidelines. Furthermore, this review critically examines each domain, identifies current challenges, and proposes future research directions, emphasizing the potential of AI methods in transforming health monitoring and patient care.

Abstract
The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing ex vivo tissues in agents or by topical application of those agents in vivo, their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.

Abstract
Colorectal cancer is the second most common cancer and the second with the highest associated deaths in the world. Methods used in clinical practice for colon cancer diagnosis are fairly effective but quite unpleasant and not always applicable in situations where the patient has symptoms of colonic obstruction. This problem can be solved by the use of optical methods that can be applied less invasively. This study presents the results of classification of cancerous and healthy colon tissue absorption coefficient spectra. The absorption coefficient was measured using direct calculations from the total reflectance and total transmittance spectra obtained ex vivo. Classification was performed using support vector machine, multilayer perceptron and linear discriminant analysis.