Abstract
1110 Background: The international randomised contolled TARGeted Intraoperative radioTherapy (TARGIT) trial has demonstrated non-inferiority between the novel technique of TARGIT (intra-operative radiotherapy with Intrabeam) and conventional whole-breast external beam radiotherapy (EBRT) in women with early breast cancer, in terms of the primary outcome measure of risk of local relapse within the treated breast. With very low recurrence rates, cosmesis becomes an increasingly important outcome of breast conserving treatment with both surgery and radiotherapy. This study was performed to determine if the single high dose of TARGIT leads to impaired cosmesis. Methods: A validated, objective assessment tool for evaluation of cosmetic outcome was used. Frontal digital photographs were taken at baseline (before TARGIT or EBRT) and yearly thereafter for up to five years. The photographs were analysed by BCCT.core software which produces a composite score based on symmetry, colour and scar. Results: 342 patients were assessed, all over 50 years old with a median age at baseline of 64 years (IQR 59 to 68). The scores were dichotomised into Excellent and Good (EG), and Fair and Poor (FP). There were statistically significant increases in the odds of having an outcome of EG for patients in the TARGIT group relative to the EBRT group at year 1 (OR = 2.07, 95%CI 1.12 to 3.85, p = 0.021) and year 2 (OR = 2.11, 95%CI 1.0 to 4.45, p = 0.05). Conclusions: Following an objective assessment of aesthetic outcome in patients from a randomised setting, this study demonstrates that those treated with targeted intraoperative radiotherapy have a superior cosmetic result compared with those patients who received conventional whole-breast external beam radiotherapy.

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This paper describes the design and development of a tablet-based gaming platform targeting the senior population, aiming at improving their overall wellbeing by stimulating their cognitive capabilities and promoting social interaction between players. To achieve these goals, we started by performing a study of the specific characteristics of the senior user as well as what makes a game appealing to the player. Furthermore we investigated why the tablet proves to be an advantageous device to our target audience. Based on the results of our research, we developed a solution that incorporates cognitive and social mechanisms into its games, while performing iterative evaluations together with the final user by adopting a user-centered design methodology. In each design phase, a pre-selected group of senior participants experimented with the game platform and provided feedback to improve its features and usability. Through a series of short-term and a long-term evaluation, the game platform proved to be appealing to its intended users, providing an enjoyable gaming experience.

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This paper describes the creative and technical processes behind earGram, an application created with Pure Data for real-time concatenative sound synthesis. The system encompasses four generative music strategies that automatically rearrange and explore a database of descriptor-analyzed sound snippets (corpus) by rules other than their original temporal order into musically coherent outputs. Of note are the system's machine-learning capabilities as well as its visualization strategies, which constitute a valuable aid for decision-making during performance by revealing musical patterns and temporal organizations of the corpus.

Abstract
Spatial solitons are robust localized nonlinear waves that are able to propagate without significant changes to their structure. Most of the proposal of the application of solitons uses them to transmit and process information in optical fibers and optical circuits. In the later the solitons can be guided through different paths by presetting some soliton characteristics (such as the phase), and even using some solitons to control the path of other pulses. In this paper, we use these properties of optical spatial solitons in a cubic nonlinear media to have lightons: phonon-like oscillations of a chain of solitonic light pulses. Conceptually, this work aims to explore the dual nature of solitons as a particle-like wave, by considering the displacement wave of solitons in a 1-dimensional chain.