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Biomedical Engineering Research

At C-BER our main goals are the creation of interdisciplinary knowledge enabling innovation and technology transfer with economic impact; and also the development of products, tools and methods for the prevention and early detection of different types of diseases, aging-related impairments, or for human rehabilitation, physical therapy or functional assessment.

We also seek to contribute to the development of advanced neuro-technologies at the frontier of engineering and neurology, and to promote strategic partnerships with clinical partners, research institutes, and fostering international cooperation.

Our R&D activity is developed in three different areas: BioInstrumentation, Biomedical Imaging and NeuroEngineering.

Latest News
Networked Intelligent Systems

Innovation in breast cancer diagnosis published by INESC TEC

Breast cancer is currently one of the main causes of death by oncological disease worldwide.

18th June 2017

INESC TEC researchers output highlighted in Japan

Pedro Costa, CMU-Portugal, and Aurélio Campilho, coordinator of the INESC TEC’s Centre for Biomedical Engineering Research (C-BER), presented a scientific paper at the International Conference on Image Analysis Applications (IAPR MVA 2017), and it was highlighted with some special references.

24th May 2017

Networked Intelligent Systems

Paper by INESC TEC is esteemed paper in international journal

The paper entitled "Optic disc segmentation using the sliding band filter”, written by Aurélio Campilho and Ana Maria Mendonça, researchers at INESC TEC’s Centre for Biomedical Engineering Research (C-BER), and Behdad Dashtbozorg, former student of the PhD in Electrical and Computer Engineering at the Faculty of Engineering of the University of Porto (FEUP), is an esteemed paper of the international journal Computers in Biology and Medicine Journal.

01st July 2016

Networked Intelligent Systems

INESC TEC creates 1st 3D video system in the world to help patients with epilepsy

A team of researchers from INESC TEC’s Centre for Biomedical Engineering Research (C-BER), led by João Paulo Cunha, have created the first system in the world to use 3D video technology to extract body movements during epileptic seizures. This new system can help health professionals to diagnose patients and define therapies, not only for epilepsy patients, but also for patients with other neurological illnesses, such as Parkinson’s.

03rd February 2016

Networked Intelligent Systems

INESC TEC poster awarded in Germany

A poster co-authored by João Paulo Cunha, coordinator of INESC TEC’s Centre for Biomedical Engineering Research (C-BER), won 2nd place for best poster as part of the 23rd Annual Meeting of the German Society for Sleep Research and Sleep Medicine (DGSM), which took place in Mainz, Germany, on 4 December.

21st December 2015

Interest Topics

Featured Projects


Automatic Detection, Segmentation and Classification of Pulmonary Nodules System in Computed Tomography Images



Image Analysis and Machine Learning Platform for Innovation in Diabetic Retinopathy Screening



Projeto Vital Sticker no âmbito do Contrato Programa



NanoSTIMA – Advanced Methodologies for Computer-Aided Detection and Diagnosis



NanoSTIMA – Macro-to-Nano Human Sensing Technologies



SMILES - Smart, Mobile, Intelligent and Large scale Sensing and analytics



VR2Market: Towards a Mobile Wearable Health Surveillance Product for First Response and other Hazardous Professions



Spatio-temporal components of the processing of sensorial and motor information



Inteligent Eco Driving and Fleet Management



Human motor re-learning by sensor information fusion



Intelligent management of critical events of stress, fatigue and smoke intoxication in forest firefighting



Movement Disorders in Autistic Spectrum Disorders



Interactive system for digital content consumers




Biomedical Imaging Laboratory

Neuroengineering and Advanced Human Sensing Laboratory

BioInstrumentation Lab


C-BER Publications

View all Publications


Retinal image quality assessment by mean-subtracted contrast-normalized coefficients

Galdran, A; Araújo, T; Mendonça, AM; Campilho, A;

Lecture Notes in Computational Vision and Biomechanics

The automatic assessment of visual quality on images of the eye fundus is an important task in retinal image analysis. A novel quality assessment technique is proposed in this paper. We propose to compute Mean-Subtracted Contrast-Normalized (MSCN) coefficients on local spatial neighborhoods of a given image and analyze their distribution. It is known that for natural images, such distribution behaves normally, while distortions of different kinds perturb this regularity. The combination of MSCN coefficients with a simple measure of local contrast allows us to design a simple but effective retinal image quality assessment algorithm that successfully discriminates between good and low-quality images, while delivering a meaningful quality score. The proposed technique is validated on a recent database of quality-labeled retinal images, obtaining results aligned with state-of-the-art approaches at a low computational cost. © 2018, Springer International Publishing AG.


Innovative analysis of 3D pelvis coordination on modified gait mode

Rodrigues, C; Correia, MV; Abrantes, JMCS; Nadal, J; Rodrigues, MAB;

Lecture Notes in Computational Vision and Biomechanics

This study presents innovative analysis at the time, frequency and phase domain of the pelvis angular oscillation at transverse (T), sagittal (S) and coronal (C) planes, assessing its coordination during stiff knee gait (SKG) and slow running (SR) comparing it to normal gait (NG). Case study is considered of an adult male 70 kg mass and 1.86 m height. Computer vision is used with 8 Qualysis 100 Hz cameras tracking position of right and left anterior and posterior superior iliac spine (RAsis, LAsis, RPsis, LPsis) including one complete stride during NG, SKG and SR. 3D position coordinates are obtained from 2D image coordinate of multiple camera image using direct linear transformation (DLT). Inverse kinematics is performed using cartesian position data of RAsis, LAsis, RPsis, LPsis and scaled model to subject dimension. The angles, angular velocities and angular accelerations coordination of the pelvis oscillation at T, S, C planes were assessed using linear and cross correlation analysis (LCA, CCA), fast Fourier transform (FFT) and phase space analysis (PSA). Results point for important complementary analysis on entire series of time, frequency and phase analysis of human movement such as the pelvis coordination assessment on different gait modes. © 2018, Springer International Publishing AG.


Optical Fiber Tips for Biological Applications: from Light Confinement, Biosensing to Bioparticles Manipulation

Paiva, JS; Jorge, PA; Rosa, CC; Cunha, JP;

Biochimica et Biophysica Acta (BBA) - General Subjects



3D mapping of choroidal thickness from OCT B-scans

Faria, SP; Penas, S; Mendonça, L; Silva, JA; Mendonça, AM;

Lecture Notes in Computational Vision and Biomechanics

The choroid is the middle layer of the eye globe located between the retina and the sclera. It is proven that choroidal thickness is a sign of multiple eye diseases. Optical Coherence Tomography (OCT) is an imaging technique that allows the visualization of tomographic images of near surface tissues like those in the eye globe. The automatic calculation of the choroidal thickness reduces the subjectivity of manual image analysis as well as the time of large scale measurements. In this paper, a method for the automatic estimation of the choroidal thickness from OCT images is presented. The pre-processing of the images is focused on noise reduction, shadow removal and contrast adjustment. The inner and outer boundaries of the choroid are delineated sequentially, resorting to a minimum path algorithm supported by new dedicated cost matrices. The choroidal thickness is given by the distance between the two boundaries. The data are then interpolated and mapped to an infrared image of the eye fundus. The method was evaluated by calculating the error as the distance from the automatically estimated boundaries to the boundaries delineated by an ophthalmologist. The error of the automatic segmentation was low and comparable to the differences between manual segmentations from different ophthalmologists. © 2018, Springer International Publishing AG.


Analysis and quantification of upper-limb movement in motor rehabilitation after stroke

Silva, RM; Sousa, E; Fonseca, P; Pinheiro, AR; Silva, C; Correia, MV; Mouta, S;

Biosystems and Biorobotics

It is extremely difficult to reduce the relations between the several body parts that perform human motion to a simplified set of features. Therefore, the study of the upper-limb functionality is still in development, partly due to the wider range of actions and strategies for motor execution. This, in turn, leads to inconsistent upper-limb movement parameterization. We propose a methodology to assess and quantify the upper-limb motor execution. Extracting key variables from different sources, we intended to quantify healthy upper-limb movement and use these parameters to quantify motor execution during rehabilitation after stroke. In order to do so, we designed an experimental setup defining a workspace for the execution of the action recording kinematic data. Results reveal an effect of object and instruction on the timing of upper-limb movement, indicating that the spatiotemporal analysis of kinematic data can be used as a quantification parameter for motor rehabilitation stages and methods. © Springer International Publishing AG 2017.

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