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Biomedical Engineering Research

At C-BER our main goals are the creation of interdisciplinary knowledge enabling innovation and technology transfer with economic impact; and also the development of products, tools and methods for the prevention and early detection of different types of diseases, aging-related impairments, or for human rehabilitation, physical therapy or functional assessment.

We also seek to contribute to the development of advanced neuro-technologies at the frontier of engineering and neurology, and to promote strategic partnerships with clinical partners, research institutes, and fostering international cooperation.

Our R&D activity is developed in three different areas: BioInstrumentation, Biomedical Imaging and NeuroEngineering.

Latest News
Networked Intelligent Systems

Innovation in breast cancer diagnosis published by INESC TEC

Breast cancer is currently one of the main causes of death by oncological disease worldwide.

18th June 2017

INESC TEC researchers output highlighted in Japan

Pedro Costa, CMU-Portugal, and Aurélio Campilho, coordinator of the INESC TEC’s Centre for Biomedical Engineering Research (C-BER), presented a scientific paper at the International Conference on Image Analysis Applications (IAPR MVA 2017), and it was highlighted with some special references.

24th May 2017

Networked Intelligent Systems

Paper by INESC TEC is esteemed paper in international journal

The paper entitled "Optic disc segmentation using the sliding band filter”, written by Aurélio Campilho and Ana Maria Mendonça, researchers at INESC TEC’s Centre for Biomedical Engineering Research (C-BER), and Behdad Dashtbozorg, former student of the PhD in Electrical and Computer Engineering at the Faculty of Engineering of the University of Porto (FEUP), is an esteemed paper of the international journal Computers in Biology and Medicine Journal.

01st July 2016

Networked Intelligent Systems

INESC TEC creates 1st 3D video system in the world to help patients with epilepsy

A team of researchers from INESC TEC’s Centre for Biomedical Engineering Research (C-BER), led by João Paulo Cunha, have created the first system in the world to use 3D video technology to extract body movements during epileptic seizures. This new system can help health professionals to diagnose patients and define therapies, not only for epilepsy patients, but also for patients with other neurological illnesses, such as Parkinson’s.

03rd February 2016

Networked Intelligent Systems

INESC TEC poster awarded in Germany

A poster co-authored by João Paulo Cunha, coordinator of INESC TEC’s Centre for Biomedical Engineering Research (C-BER), won 2nd place for best poster as part of the 23rd Annual Meeting of the German Society for Sleep Research and Sleep Medicine (DGSM), which took place in Mainz, Germany, on 4 December.

21st December 2015

Interest Topics
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Featured Projects

LNDetector

Automatic Detection, Segmentation and Classification of Pulmonary Nodules System in Computed Tomography Images

2016-2019

SCREEN-DR

Image Analysis and Machine Learning Platform for Innovation in Diabetic Retinopathy Screening

2016-2020

Bio-Early

Projeto Vital Sticker no âmbito do Contrato Programa

2015-2017

NanoStima-RL5

NanoSTIMA – Advanced Methodologies for Computer-Aided Detection and Diagnosis

2015-2018

NanoStima-RL1

NanoSTIMA – Macro-to-Nano Human Sensing Technologies

2015-2018

SMILES

SMILES - Smart, Mobile, Intelligent and Large scale Sensing and analytics

2015-2018

VR2Market

VR2Market: Towards a Mobile Wearable Health Surveillance Product for First Response and other Hazardous Professions

2014-2018

STePMotion

Spatio-temporal components of the processing of sensorial and motor information

2014-2015

EcoDrive

Inteligent Eco Driving and Fleet Management

2014-2015

Re-Learning

Human motor re-learning by sensor information fusion

2014-2015

VitalResponder2

Intelligent management of critical events of stress, fatigue and smoke intoxication in forest firefighting

2013-2015

ASD-MD

Movement Disorders in Autistic Spectrum Disorders

2013-2015

HERMES

Interactive system for digital content consumers

2013-2015

Team
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Laboratories

Biomedical Imaging Laboratory

Neuroengineering and Advanced Human Sensing Laboratory

BioInstrumentation Lab

Publications

C-BER Publications

View all Publications

2018

Retinal image quality assessment by mean-subtracted contrast-normalized coefficients

Authors
Galdran, A; Araújo, T; Mendonça, AM; Campilho, A;

Publication
Lecture Notes in Computational Vision and Biomechanics

Abstract
The automatic assessment of visual quality on images of the eye fundus is an important task in retinal image analysis. A novel quality assessment technique is proposed in this paper. We propose to compute Mean-Subtracted Contrast-Normalized (MSCN) coefficients on local spatial neighborhoods of a given image and analyze their distribution. It is known that for natural images, such distribution behaves normally, while distortions of different kinds perturb this regularity. The combination of MSCN coefficients with a simple measure of local contrast allows us to design a simple but effective retinal image quality assessment algorithm that successfully discriminates between good and low-quality images, while delivering a meaningful quality score. The proposed technique is validated on a recent database of quality-labeled retinal images, obtaining results aligned with state-of-the-art approaches at a low computational cost. © 2018, Springer International Publishing AG.

2018

Innovative analysis of 3D pelvis coordination on modified gait mode

Authors
Rodrigues, C; Correia, MV; Abrantes, JMCS; Nadal, J; Rodrigues, MAB;

Publication
Lecture Notes in Computational Vision and Biomechanics

Abstract
This study presents innovative analysis at the time, frequency and phase domain of the pelvis angular oscillation at transverse (T), sagittal (S) and coronal (C) planes, assessing its coordination during stiff knee gait (SKG) and slow running (SR) comparing it to normal gait (NG). Case study is considered of an adult male 70 kg mass and 1.86 m height. Computer vision is used with 8 Qualysis 100 Hz cameras tracking position of right and left anterior and posterior superior iliac spine (RAsis, LAsis, RPsis, LPsis) including one complete stride during NG, SKG and SR. 3D position coordinates are obtained from 2D image coordinate of multiple camera image using direct linear transformation (DLT). Inverse kinematics is performed using cartesian position data of RAsis, LAsis, RPsis, LPsis and scaled model to subject dimension. The angles, angular velocities and angular accelerations coordination of the pelvis oscillation at T, S, C planes were assessed using linear and cross correlation analysis (LCA, CCA), fast Fourier transform (FFT) and phase space analysis (PSA). Results point for important complementary analysis on entire series of time, frequency and phase analysis of human movement such as the pelvis coordination assessment on different gait modes. © 2018, Springer International Publishing AG.

2018

3D mapping of choroidal thickness from OCT B-scans

Authors
Faria, SP; Penas, S; Mendonça, L; Silva, JA; Mendonça, AM;

Publication
Lecture Notes in Computational Vision and Biomechanics

Abstract
The choroid is the middle layer of the eye globe located between the retina and the sclera. It is proven that choroidal thickness is a sign of multiple eye diseases. Optical Coherence Tomography (OCT) is an imaging technique that allows the visualization of tomographic images of near surface tissues like those in the eye globe. The automatic calculation of the choroidal thickness reduces the subjectivity of manual image analysis as well as the time of large scale measurements. In this paper, a method for the automatic estimation of the choroidal thickness from OCT images is presented. The pre-processing of the images is focused on noise reduction, shadow removal and contrast adjustment. The inner and outer boundaries of the choroid are delineated sequentially, resorting to a minimum path algorithm supported by new dedicated cost matrices. The choroidal thickness is given by the distance between the two boundaries. The data are then interpolated and mapped to an infrared image of the eye fundus. The method was evaluated by calculating the error as the distance from the automatically estimated boundaries to the boundaries delineated by an ophthalmologist. The error of the automatic segmentation was low and comparable to the differences between manual segmentations from different ophthalmologists. © 2018, Springer International Publishing AG.

2017

Analysis and quantification of upper-limb movement in motor rehabilitation after stroke

Authors
Silva, RM; Sousa, E; Fonseca, P; Pinheiro, AR; Silva, C; Correia, MV; Mouta, S;

Publication
Biosystems and Biorobotics

Abstract
It is extremely difficult to reduce the relations between the several body parts that perform human motion to a simplified set of features. Therefore, the study of the upper-limb functionality is still in development, partly due to the wider range of actions and strategies for motor execution. This, in turn, leads to inconsistent upper-limb movement parameterization. We propose a methodology to assess and quantify the upper-limb motor execution. Extracting key variables from different sources, we intended to quantify healthy upper-limb movement and use these parameters to quantify motor execution during rehabilitation after stroke. In order to do so, we designed an experimental setup defining a workspace for the execution of the action recording kinematic data. Results reveal an effect of object and instruction on the timing of upper-limb movement, indicating that the spatiotemporal analysis of kinematic data can be used as a quantification parameter for motor rehabilitation stages and methods. © Springer International Publishing AG 2017.

2017

Consistency of surface electromyography assessment at lower limb selected muscles during vertical countermovement

Authors
Rodrigues, C; Correia, M; Abrantes, JMCS; Nadal, J; Rodrigues, MAB;

Publication
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Abstract
Given the difficulty of invasive methods to assess muscle action during natural human movement, surface electromyography (sEMG) has been increasingly used to capture muscle activity in relation to kinesiological analysis of specific tasks. Isolated isometric, concentric and eccentric forms of muscle action have been receiving the most attention for research purposes. Nevertheless natural muscle action frequently involves the use of a preceding eccentric muscle action as a form of potentiation of immediate muscle concentric action, in what is designated as muscle stretch-shortening cycle (SSC). The most frequently applied protocols for the evaluation of SSC on vertical jumps are by virtue of their reproducibility and control of experimental conditions, squat jump (SJ) without countermovement (CM), countermovement jump (CMJ) with long CM and drop jump (DJ) with short CM. The methods used to extract information and relationship of the captured signals also present a high diversity, with the question about the consistency of the methods and obtained results. The objective of this study is to evaluate the consistency of the analysis and results by applying different EMGs signal analysis techniques related to strategic muscle groups of the lower limbs at different countermovement evaluated in vertical jumps. Raw sEMG signals of 5 lower limb muscles of 6 subjects during SJ, CMJ and DJ were rectified, filtered and obtained their envelope, and then correlated (CR) for detection of synergistic, agonist and antagonist activity, applied principal component analysis (PCA) for the detection of uncorrelated components explaining maximum variability and normalized cross-correlation (CCRN) for detection of maximum correlations and time lag. CR of EMG envelopes presented higher coactivities (CoA) in DJ relative to SJ and these CoA superior to CMJ with greater synergy in DJ relative to SJ and CMJ that present several loop cycles corresponding to time lag of activity. CCRN of the EMG envelopes presented also higher CoA in DJ when compared to SJ and both higher CoA to CMJ. PCA allowed to detect a principal component (PC) explaining 92.2% of the variability of EMG in DJ, 90.6% in SJ and 78.7% in CMJ, the second PC responsible for the explanation of 4.9% variability in DJ, 6.7% in SJ and 15.3% in CMJ. © 2017 IEEE.

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6Academic Staff

2017

3R&D Employees

2017

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